Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration.
Identifieur interne : 000337 ( Main/Exploration ); précédent : 000336; suivant : 000338Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration.
Auteurs : Juan Ignacio Romero [Argentine] ; Mariana Inés Holubiec [Argentine] ; Tamara Logica Tornatore [Argentine] ; Stéphanie Rivière [Argentine] ; Eva-Maria Hanschmann [Allemagne] ; Rodolfo Alberto Kölliker-Frers [Argentine] ; Julia Tau [Argentine] ; Eduardo Blanco [Espagne] ; Pablo Galeano [Argentine] ; Fernando Rodríguez De Fonseca [Espagne] ; Christopher Horst Lillig [Allemagne] ; Francisco Capani [Argentine, Chili]Source :
- Oxidative medicine and cellular longevity [ 1942-0994 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Animaux nouveau-nés (MeSH), Asphyxie (complications), Glutarédoxines (administration et posologie), Glutarédoxines (pharmacologie), Glutarédoxines (usage thérapeutique), Hypoxie-ischémie du cerveau (anatomopathologie), Hypoxie-ischémie du cerveau (métabolisme), Modèles animaux de maladie humaine (MeSH), Mâle (MeSH), Neurones (anatomopathologie), Rats (MeSH).
- MESH :
- administration et posologie : Glutarédoxines.
- anatomopathologie : Hypoxie-ischémie du cerveau, Neurones.
- métabolisme : Hypoxie-ischémie du cerveau.
- pharmacologie : Glutarédoxines.
- usage thérapeutique : Glutarédoxines.
- complications : Animaux, Animaux nouveau-nés, Asphyxie, Modèles animaux de maladie humaine, Mâle, Rats.
English descriptors
- KwdEn :
- Animals (MeSH), Animals, Newborn (MeSH), Asphyxia (complications), Disease Models, Animal (MeSH), Glutaredoxins (administration & dosage), Glutaredoxins (pharmacology), Glutaredoxins (therapeutic use), Hypoxia-Ischemia, Brain (metabolism), Hypoxia-Ischemia, Brain (pathology), Male (MeSH), Neurons (pathology), Rats (MeSH).
- MESH :
- chemical , administration & dosage : Glutaredoxins.
- complications : Asphyxia.
- metabolism : Hypoxia-Ischemia, Brain.
- pathology : Hypoxia-Ischemia, Brain, Neurons.
- chemical , pharmacology : Glutaredoxins.
- chemical , therapeutic use : Glutaredoxins.
- Animals, Animals, Newborn, Disease Models, Animal, Male, Rats.
Abstract
The general disruption of redox signaling following an ischemia-reperfusion episode has been proposed as a crucial component in neuronal death and consequently brain damage. Thioredoxin (Trx) family proteins control redox reactions and ensure protein regulation via specific, oxidative posttranslational modifications as part of cellular signaling processes. Trx proteins function in the manifestation, progression, and recovery following hypoxic/ischemic damage. Here, we analyzed the neuroprotective effects of postinjury, exogenous administration of Grx2 and Trx1 in a neonatal hypoxia/ischemia model. P7 Sprague-Dawley rats were subjected to right common carotid ligation or sham surgery, followed by an exposure to nitrogen. 1 h later, animals were injected i.p. with saline solution, 10 mg/kg recombinant Grx2 or Trx1, and euthanized 72 h postinjury. Results showed that Grx2 administration, and to some extent Trx1, attenuated part of the neuronal damage associated with a perinatal hypoxic/ischemic damage, such as glutamate excitotoxicity, axonal integrity, and astrogliosis. Moreover, these treatments also prevented some of the consequences of the induced neural injury, such as the delay of neurobehavioral development. To our knowledge, this is the first study demonstrating neuroprotective effects of recombinant Trx proteins on the outcome of neonatal hypoxia/ischemia, implying clinical potential as neuroprotective agents that might counteract neonatal hypoxia/ischemia injury.
DOI: 10.1155/2017/4162465
PubMed: 28706574
PubMed Central: PMC5494587
Affiliations:
- Allemagne, Argentine, Chili, Espagne
- Andalousie, Catalogne, District de Düsseldorf, Rhénanie-du-Nord-Westphalie
- Düsseldorf
Links toward previous steps (curation, corpus...)
Le document en format XML
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Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. 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Patricias Argentinas 435, C1405BWE, Ciudad Autónoma de Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Fundación Instituto Leloir, Av. Patricias Argentinas 435, C1405BWE, Ciudad Autónoma de Buenos Aires</wicri:regionArea><wicri:noRegion>Ciudad Autónoma de Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez De Fonseca, Fernando" sort="Rodriguez De Fonseca, Fernando" uniqKey="Rodriguez De Fonseca F" first="Fernando" last="Rodríguez De Fonseca">Fernando Rodríguez De Fonseca</name><affiliation wicri:level="2"><nlm:affiliation>Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Universidad de Málaga, Avda. Carlos Haya 82, 29010 Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Universidad de Málaga, Avda. Carlos Haya 82, 29010 Málaga</wicri:regionArea><placeName><region nuts="2" type="communauté">Andalousie</region></placeName></affiliation></author><author><name sortKey="Lillig, Christopher Horst" sort="Lillig, Christopher Horst" uniqKey="Lillig C" first="Christopher Horst" last="Lillig">Christopher Horst Lillig</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-Universität Greifswald, 17475 Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-Universität Greifswald, 17475 Greifswald</wicri:regionArea><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Capani, Francisco" sort="Capani, Francisco" uniqKey="Capani F" first="Francisco" last="Capani">Francisco Capani</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires</wicri:regionArea><wicri:noRegion>Ciudad de Buenos Aires</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Departamento de Biología, Universidad Argentina JF Kennedy, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Departamento de Biología, Universidad Argentina JF Kennedy, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Investigador Asociado, Universidad Autónoma de Chile, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Investigador Asociado, Universidad Autónoma de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28706574</idno><idno type="pmid">28706574</idno><idno type="doi">10.1155/2017/4162465</idno><idno type="pmc">PMC5494587</idno><idno type="wicri:Area/Main/Corpus">000323</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000323</idno><idno type="wicri:Area/Main/Curation">000323</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000323</idno><idno type="wicri:Area/Main/Exploration">000323</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration.</title><author><name sortKey="Romero, Juan Ignacio" sort="Romero, Juan Ignacio" uniqKey="Romero J" first="Juan Ignacio" last="Romero">Juan Ignacio Romero</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires</wicri:regionArea><wicri:noRegion>Ciudad de Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Holubiec, Mariana Ines" sort="Holubiec, Mariana Ines" uniqKey="Holubiec M" first="Mariana Inés" last="Holubiec">Mariana Inés Holubiec</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires</wicri:regionArea><wicri:noRegion>Ciudad de Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Tornatore, Tamara Logica" sort="Tornatore, Tamara Logica" uniqKey="Tornatore T" first="Tamara Logica" last="Tornatore">Tamara Logica Tornatore</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires</wicri:regionArea><wicri:noRegion>Ciudad de Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Riviere, Stephanie" sort="Riviere, Stephanie" uniqKey="Riviere S" first="Stéphanie" last="Rivière">Stéphanie Rivière</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires</wicri:regionArea><wicri:noRegion>Ciudad de Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Hanschmann, Eva Maria" sort="Hanschmann, Eva Maria" uniqKey="Hanschmann E" first="Eva-Maria" last="Hanschmann">Eva-Maria Hanschmann</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute for Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-Universität Greifswald, 17475 Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-Universität Greifswald, 17475 Greifswald</wicri:regionArea><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Kolliker Frers, Rodolfo Alberto" sort="Kolliker Frers, Rodolfo Alberto" uniqKey="Kolliker Frers R" first="Rodolfo Alberto" last="Kölliker-Frers">Rodolfo Alberto Kölliker-Frers</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires</wicri:regionArea><wicri:noRegion>Ciudad de Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Tau, Julia" sort="Tau, Julia" uniqKey="Tau J" first="Julia" last="Tau">Julia Tau</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Ocular Investigation, Department of Pathology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratory of Ocular Investigation, Department of Pathology, School of Medicine, University of Buenos Aires, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Blanco, Eduardo" sort="Blanco, Eduardo" uniqKey="Blanco E" first="Eduardo" last="Blanco">Eduardo Blanco</name><affiliation wicri:level="2"><nlm:affiliation>Departament de Pedagogia i Psicologia, Facultat d''Educació, Psicologia i Treball Social, Universitat de Lleida, Avda. de l'Estudi General 4, 25001 Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament de Pedagogia i Psicologia, Facultat d''Educació, Psicologia i Treball Social, Universitat de Lleida, Avda. de l'Estudi General 4, 25001 Lleida</wicri:regionArea><placeName><region nuts="2" type="communauté">Catalogne</region></placeName></affiliation></author><author><name sortKey="Galeano, Pablo" sort="Galeano, Pablo" uniqKey="Galeano P" first="Pablo" last="Galeano">Pablo Galeano</name><affiliation wicri:level="1"><nlm:affiliation>Fundación Instituto Leloir, Av. Patricias Argentinas 435, C1405BWE, Ciudad Autónoma de Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Fundación Instituto Leloir, Av. Patricias Argentinas 435, C1405BWE, Ciudad Autónoma de Buenos Aires</wicri:regionArea><wicri:noRegion>Ciudad Autónoma de Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez De Fonseca, Fernando" sort="Rodriguez De Fonseca, Fernando" uniqKey="Rodriguez De Fonseca F" first="Fernando" last="Rodríguez De Fonseca">Fernando Rodríguez De Fonseca</name><affiliation wicri:level="2"><nlm:affiliation>Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Universidad de Málaga, Avda. Carlos Haya 82, 29010 Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Universidad de Málaga, Avda. Carlos Haya 82, 29010 Málaga</wicri:regionArea><placeName><region nuts="2" type="communauté">Andalousie</region></placeName></affiliation></author><author><name sortKey="Lillig, Christopher Horst" sort="Lillig, Christopher Horst" uniqKey="Lillig C" first="Christopher Horst" last="Lillig">Christopher Horst Lillig</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-Universität Greifswald, 17475 Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-Universität Greifswald, 17475 Greifswald</wicri:regionArea><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Capani, Francisco" sort="Capani, Francisco" uniqKey="Capani F" first="Francisco" last="Capani">Francisco Capani</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires</wicri:regionArea><wicri:noRegion>Ciudad de Buenos Aires</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Departamento de Biología, Universidad Argentina JF Kennedy, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Departamento de Biología, Universidad Argentina JF Kennedy, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Investigador Asociado, Universidad Autónoma de Chile, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Investigador Asociado, Universidad Autónoma de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oxidative medicine and cellular longevity</title><idno type="eISSN">1942-0994</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Animals, Newborn (MeSH)</term><term>Asphyxia (complications)</term><term>Disease Models, Animal (MeSH)</term><term>Glutaredoxins (administration & dosage)</term><term>Glutaredoxins (pharmacology)</term><term>Glutaredoxins (therapeutic use)</term><term>Hypoxia-Ischemia, Brain (metabolism)</term><term>Hypoxia-Ischemia, Brain (pathology)</term><term>Male (MeSH)</term><term>Neurons (pathology)</term><term>Rats (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Animaux nouveau-nés (MeSH)</term><term>Asphyxie (complications)</term><term>Glutarédoxines (administration et posologie)</term><term>Glutarédoxines (pharmacologie)</term><term>Glutarédoxines (usage thérapeutique)</term><term>Hypoxie-ischémie du cerveau (anatomopathologie)</term><term>Hypoxie-ischémie du cerveau (métabolisme)</term><term>Modèles animaux de maladie humaine (MeSH)</term><term>Mâle (MeSH)</term><term>Neurones (anatomopathologie)</term><term>Rats (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Glutaredoxins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Glutarédoxines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Hypoxie-ischémie du cerveau</term><term>Neurones</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Asphyxia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hypoxia-Ischemia, Brain</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Hypoxie-ischémie du cerveau</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hypoxia-Ischemia, Brain</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Glutarédoxines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Glutaredoxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Glutaredoxins</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Glutarédoxines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Disease Models, Animal</term><term>Male</term><term>Rats</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés</term><term>Asphyxie</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The general disruption of redox signaling following an ischemia-reperfusion episode has been proposed as a crucial component in neuronal death and consequently brain damage. Thioredoxin (Trx) family proteins control redox reactions and ensure protein regulation via specific, oxidative posttranslational modifications as part of cellular signaling processes. Trx proteins function in the manifestation, progression, and recovery following hypoxic/ischemic damage. Here, we analyzed the neuroprotective effects of postinjury, exogenous administration of Grx2 and Trx1 in a neonatal hypoxia/ischemia model. P7 Sprague-Dawley rats were subjected to right common carotid ligation or sham surgery, followed by an exposure to nitrogen. 1 h later, animals were injected i.p. with saline solution, 10 mg/kg recombinant Grx2 or Trx1, and euthanized 72 h postinjury. Results showed that Grx2 administration, and to some extent Trx1, attenuated part of the neuronal damage associated with a perinatal hypoxic/ischemic damage, such as glutamate excitotoxicity, axonal integrity, and astrogliosis. Moreover, these treatments also prevented some of the consequences of the induced neural injury, such as the delay of neurobehavioral development. To our knowledge, this is the first study demonstrating neuroprotective effects of recombinant Trx proteins on the outcome of neonatal hypoxia/ischemia, implying clinical potential as neuroprotective agents that might counteract neonatal hypoxia/ischemia injury.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28706574</PMID><DateCompleted><Year>2018</Year><Month>04</Month><Day>10</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1942-0994</ISSN><JournalIssue CitedMedium="Internet"><Volume>2017</Volume><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Oxidative medicine and cellular longevity</Title><ISOAbbreviation>Oxid Med Cell Longev</ISOAbbreviation></Journal><ArticleTitle>Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration.</ArticleTitle><Pagination><MedlinePgn>4162465</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2017/4162465</ELocationID><Abstract><AbstractText>The general disruption of redox signaling following an ischemia-reperfusion episode has been proposed as a crucial component in neuronal death and consequently brain damage. Thioredoxin (Trx) family proteins control redox reactions and ensure protein regulation via specific, oxidative posttranslational modifications as part of cellular signaling processes. Trx proteins function in the manifestation, progression, and recovery following hypoxic/ischemic damage. Here, we analyzed the neuroprotective effects of postinjury, exogenous administration of Grx2 and Trx1 in a neonatal hypoxia/ischemia model. P7 Sprague-Dawley rats were subjected to right common carotid ligation or sham surgery, followed by an exposure to nitrogen. 1 h later, animals were injected i.p. with saline solution, 10 mg/kg recombinant Grx2 or Trx1, and euthanized 72 h postinjury. Results showed that Grx2 administration, and to some extent Trx1, attenuated part of the neuronal damage associated with a perinatal hypoxic/ischemic damage, such as glutamate excitotoxicity, axonal integrity, and astrogliosis. Moreover, these treatments also prevented some of the consequences of the induced neural injury, such as the delay of neurobehavioral development. To our knowledge, this is the first study demonstrating neuroprotective effects of recombinant Trx proteins on the outcome of neonatal hypoxia/ischemia, implying clinical potential as neuroprotective agents that might counteract neonatal hypoxia/ischemia injury.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Romero</LastName><ForeName>Juan Ignacio</ForeName><Initials>JI</Initials><Identifier Source="ORCID">0000-0003-2323-0864</Identifier><AffiliationInfo><Affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holubiec</LastName><ForeName>Mariana Inés</ForeName><Initials>MI</Initials><AffiliationInfo><Affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tornatore</LastName><ForeName>Tamara Logica</ForeName><Initials>TL</Initials><AffiliationInfo><Affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rivière</LastName><ForeName>Stéphanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hanschmann</LastName><ForeName>Eva-Maria</ForeName><Initials>EM</Initials><Identifier Source="ORCID">0000-0003-1114-7262</Identifier><AffiliationInfo><Affiliation>Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute for Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-Universität Greifswald, 17475 Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kölliker-Frers</LastName><ForeName>Rodolfo Alberto</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tau</LastName><ForeName>Julia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratory of Ocular Investigation, Department of Pathology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blanco</LastName><ForeName>Eduardo</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Departament de Pedagogia i Psicologia, Facultat d''Educació, Psicologia i Treball Social, Universitat de Lleida, Avda. de l'Estudi General 4, 25001 Lleida, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galeano</LastName><ForeName>Pablo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Fundación Instituto Leloir, Av. Patricias Argentinas 435, C1405BWE, Ciudad Autónoma de Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez de Fonseca</LastName><ForeName>Fernando</ForeName><Initials>F</Initials><Identifier Source="ORCID">0000-0002-4516-5795</Identifier><AffiliationInfo><Affiliation>Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Universidad de Málaga, Avda. Carlos Haya 82, 29010 Málaga, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lillig</LastName><ForeName>Christopher Horst</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Institute for Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-Universität Greifswald, 17475 Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Capani</LastName><ForeName>Francisco</ForeName><Initials>F</Initials><Identifier Source="ORCID">0000-0003-0342-0628</Identifier><AffiliationInfo><Affiliation>Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), Facultad de Medicina, UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Ciudad de Buenos Aires, Argentina.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Departamento de Biología, Universidad Argentina JF Kennedy, Buenos Aires, Argentina.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Investigador Asociado, Universidad Autónoma de Chile, Santiago, Chile.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>06</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Oxid Med Cell Longev</MedlineTA><NlmUniqueID>101479826</NlmUniqueID><ISSNLinking>1942-0994</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000831" MajorTopicYN="N">Animals, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001237" MajorTopicYN="N">Asphyxia</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020925" MajorTopicYN="N">Hypoxia-Ischemia, Brain</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>03</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>04</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>7</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Fonseca, Fernando" sort="Rodriguez De Fonseca, Fernando" uniqKey="Rodriguez De Fonseca F" first="Fernando" last="Rodríguez De Fonseca">Fernando Rodríguez De Fonseca</name></country><country name="Chili"><noRegion><name sortKey="Capani, Francisco" sort="Capani, Francisco" uniqKey="Capani F" first="Francisco" last="Capani">Francisco Capani</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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